For healthcare professionals

Governed summaries for professionals

Concise, source-cited summaries for clinicians and allied professionals who encounter MPS I infrequently — with the limits of the evidence stated alongside each summary.

Regional applicability: Varies by country or region

In this section

01Anaesthetic considerations in Hurler syndrome (MPS I-H)People with Hurler syndrome (severe MPS I) face a heightened risk of complications around sedation, anaesthesia, and recovery.02Clinical overview of Hurler syndrome (MPS I-H)Hurler syndrome (severe MPS I, MPS I-H) is a rapidly progressive, multisystem lysosomal storage disorder caused by profound deficiency of alpha L idur.03Diagnostic algorithms for Hurler syndrome (MPS I-H)This page provides practical, stepwise diagnostic algorithms for Hurler syndrome (severe MPS I, MPS I-H).04Why follow up and registries matterHurler syndrome remains a lifelong condition, even after successful HSCT or prolonged ERT.05Guidelines and standards of care in Hurler syndrome (MPS I-H)Clinical guidelines combine the best available research evidence with expert clinical experience to describe how Hurler syndrome should be recognised,.06HSCT and ERT in Hurler syndrome: guidance for healthcare professionalsHaematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT) are the central disease-modifying treatments for Hurler syndrome .07Multisystem management in Hurler syndrome (MPS I-H)Hurler syndrome (severe MPS I, MPS I-H) is a complex multisystem disorder.08Teaching resources for healthcare professionalsAccess ready-to-use materials on Hurler syndrome (severe MPS I, MPS I-H) for clinicians, trainees, nurses, and allied health teams.

These summaries are written for professionals who meet MPS I rarely. They state what is established, what is still developing, and where individual circumstances decide. They do not substitute for specialist metabolic advice, and they are not a clinical guideline.

Summaries

Recognition and referral pathways
Diagnostic testing: enzyme assay and genetic confirmation
Multidisciplinary monitoring domains
Peri-operative and anaesthetic considerations
Established treatment approaches and where they are decided
Newborn screening: current status and jurisdictional variation

General information, not a local protocol

These summaries are general information for orientation. They do not replace local protocols, specialist metabolic advice or your own clinical judgement about a particular patient.

Where to go next

Route 01I want to understand Hurler syndromePlain-language answer Route 03I need help or supportSignposting near you

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Page governance

Clinical wording statusApproved for publication

Approval recorded23 August 2026

Review cycleWithin twelve months of publication, or sooner if guidance changes

Applies toVaries by country or region

PublisherMPS Bio — owner, publisher and data controller

Approved by the Clinical approver role for MPS Bio. We publish the review process and sources, not the names of appointed individuals.