Teaching resources for healthcare professionals
Access ready-to-use materials on Hurler syndrome (severe MPS I, MPS I-H) for clinicians, trainees, nurses, and allied health teams. Designed to support undergraduate and postgraduate teaching on diagnosis, recognition, multisystem management, and emerging therapies.
You can apply these resources in teaching sessions, journal clubs, grand rounds, and multidisciplinary meetings, tailoring them to your local protocols and context.
These materials are for educational purposes only and do not replace specialist guidance. Always follow local protocols and national recommendations.
Intended audience
These teaching resources are suitable for:
- Undergraduate medical, nursing, and allied health students
- Paediatric, metabolic, genetics, anaesthetic, and intensive care trainees
- Specialist nurses, physiotherapists, occupational therapists, and allied health professionals
- Experienced clinicians seeking concise refreshers on MPS I-H
Each resource is marked with its appropriate level: introductory, intermediate, or advanced, along with suggested teaching format.
Slide sets for lectures and teaching sessions
Download or adapt structured slide decks covering key aspects of Hurler syndrome. Each deck includes learning objectives and a brief guide for teaching.
Introduction to Hurler syndrome (MPS I-H)
Level: Introductory
Focus: Definition, causes, pathophysiology, spectrum, and natural history.
Recognition, symptoms and diagnostic pathways
Level: Intermediate
Focus: Early signs, multisystem features, newborn screening, diagnostic algorithms.
HSCT, ERT and current standard of care
Level: Intermediate–Advanced
Focus: Indications, timing, peri-transplant therapy, long-term outcomes.
Multisystem management & anaesthetic issues
Level: Advanced
Focus: Organ-specific management, MDT care, emergency & anaesthetic considerations.
Case scenarios for interactive learning
Apply knowledge to realistic clinical situations, especially valuable for rare conditions like Hurler syndrome.
Early recognition case (infant)
Focus: Hernias, ENT issues, subtle facial features, growth/development concerns.
Objective: Identify early signs and guide diagnosis.
Pre-HSCT assessment case
Focus: Multisystem evaluation, risk assessment, counselling, HSCT timing.
Objective: Integrate cardiac, respiratory, CNS, and social factors.
Peri-anaesthetic emergency case
Focus: Airway challenges, OSA, cervical spine, escalation pathways.
Objective: Highlight anaesthetic risk and MDT communication.
Long-term survivor case
Focus: Adult post-HSCT/ERT with skeletal, cardiac, psychosocial sequelae.
Objective: Understand survivorship, late effects, and adult care transition.
Journal club packs and key papers
Structured packs make it easier to include MPS I-H topics in regular teaching sessions.
Landmark HSCT outcomes
Includes key papers, discussion questions, and appraisal template.
Download packERT and combination therapy
Compare outcomes of HSCT, bridge therapy, and long-term ERT.
Download packGene therapy preclinical studies
Explore translational research using manuscripts or similar studies.
Download packPrintable summaries for ward and clinic teaching
Concise one-page handouts suitable for teaching sessions or ward prompts.
Key messages about teaching resources
- Structured, adaptable materials focused on Hurler syndrome (MPS I-H).
- Includes slide decks, case scenarios, journal club packs, and one-page checklists.
- Designed for students, trainees, clinicians, and multidisciplinary teams.
- Always align content with local guidelines; materials do not replace specialist advice.
- Feedback helps keep resources relevant and evidence-based.